论文标题
单芯片动态核极化微型系统
Single chip dynamic nuclear polarization microsystem
论文作者
论文摘要
核磁共振（NMR）和电子旋转共振（ESR）光谱仪的敏感性相关电子设备的单个芯片上的整合是提高检测极限的一种有希望的方法，尤其是对于纳米列列列列和亚硝酸盐范围的样品。在这里，我们在NMR和ESR检测器的前端电子设备的单个硅芯片上进行了协整。 NMR和ESR检测器的激发/检测平面螺旋微型机油是同心的，并询问了相同的样品体积。传感器的这种组合允许使用其面积约为2 mm $^2 $的单芯片集成微系统进行动态核极化（DNP）实验。特别是，我们报告了$^1 $ h DNP增强的NMR实验，该液体样品的体积约为1 nl，在10.7 GHz（ESR）/16 MHz（NMR）下进行。在室温下，在tempol/h $ _ {2} $ o解决方案上实现了NMR增强功能。使用最先进的亚微米集成电路技术应允许在此处提出的单芯片DNP微型系统方法的将来扩展到THZ（ESR）/GHz（NMR）区域，这对应于当前可用的最强静态磁场。特别有趣的是，有可能为纳米素和亚硝基材料样品的平行DNP增强的NMR光谱创建此类传感器阵列。
The integration on a single chip of the sensitivity-relevant electronics of nuclear magnetic resonance (NMR) and electron spin resonance (ESR) spectrometers is a promising approach to improve the limit of detection, especially for samples in the nanoliter and subnanoliter range. Here we demonstrate the co-integration on a single silicon chip of the front-end electronics of an NMR and an ESR detector. The excitation/detection planar spiral microcoils of the NMR and ESR detectors are concentric and interrogate the same sample volume. This combination of sensors allows to perform dynamic nuclear polarization (DNP) experiments using a single-chip integrated microsystem having an area of about 2 mm$^2$. In particular, we report $^1$H DNP-enhanced NMR experiments on liquid samples having a volume of about 1 nL performed at 10.7 GHz(ESR)/16 MHz(NMR). NMR enhancements as large as 50 are achieved on TEMPOL/H$_{2}$O solutions at room temperature. The use of state-of-the-art submicrometer integrated circuit technologies should allow the future extension of the single-chip DNP microsystem approach proposed here up the THz(ESR)/GHz(NMR) region, corresponding the strongest static magnetic fields currently available. Particularly interesting is the possibility to create arrays of such sensors for parallel DNP-enhanced NMR spectroscopy of nanoliter and subnanoliter samples.
