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We discuss the feasibility of measurement-based braiding in semiconductor-superconductor (SM-SC) heterostructures in the so-called quasi-Majorana regime $-$ the topologically-trivial regime due to partially-separated Andreev bound states (ps-ABSs). These low energy ABSs consist of component Majorana bound states (quasi-Majorana modes) that are spatially separated by a length scale smaller than the length of the system, in contrast with the Majorana zero modes (MZMs), which are separated by the length of the wire. In the quasi-Majorana regime, the ZBCPs appear to be robust to various perturbations as long as the energy splitting of the ps-ABS is less than the typical width $\e_w$ of the low-energy conductance peaks $\e_w$. However, the feasibility of measurement-based braiding depends on a different energy scale $\e_m$. In this paper we show that it is possible to prepare the SM-SC system in the quasi-Majorana regime with energy splittings below the $\e_m$ threshold, so that measurement-based braiding is possible in principle. Starting with ps-ABSs with energy below $\e_m$, we identify the maximum amplitudes of different types of perturbations that are consistent with perturbation-induced energy splittings not exceeding the $\e_m$ limit. We argue that measurements generating perturbations larger than the threshold amplitudes appropriate for $\e_m$ cannot realize measurement-based braiding in SM-SC heterostructures in the quasi-Majorana regime. We find that, if possible at all, quantum computation using measurement-based braiding in the quasi-Majorana regime would be plagued with errors introduced by the measurement processes themselves, while such errors are significantly less likely in a scheme involving topological MZMs.