学术文献库

Purpose: To estimate fiber-specific $T_1$ values, i.e. proxies for myelin content, in heterogeneous brain tissue. Methods: A diffusion-$T_1$ correlation experiment was carried out on an in vivo human brain using tensor-valued diffusion encoding and multiple repetition times. The acquired data was inverted using a Monte-Carlo inversion algorithm that retrieves non-parametric distributions $\mathcal{P}(\mathbf{D},R_1)$ of diffusion tensors and longitudinal relaxation rates $R_1 = 1/T_1$. Orientation distribution functions (ODFs) of the highly anisotropic components of $\mathcal{P}(\mathbf{D},R_1)$ were defined to visualize orientation-specific diffusion-relaxation properties. Finally, Monte-Carlo density-peak clustering (MC-DPC) was performed to quantify fiber-specific features and investigate microstructural differences between white-matter fiber bundles. Results: Parameter maps corresponding to $\mathcal{P}(\mathbf{D},R_1)$'s statistical descriptors were obtained, exhibiting the expected $R_1$ contrast between brain-tissue types. Our ODFs recovered local orientations consistent with the known anatomy and indicated possible differences in $T_1$ relaxation between major fiber bundles. These differences, confirmed by MC-DPC, were in qualitative agreement with previous model-based works but seem biased by the limitations of our current experimental setup. Conclusions: Our Monte-Carlo framework enables the non-parametric estimation of fiber-specific diffusion-$T_1$ features, thereby showing potential for characterizing developmental or pathological changes in $T_1$ within a given fiber bundle, and for investigating inter-bundle $T_1$ differences.