论文标题
多价聚合物颗粒的超选择性吸附
Superselective adsorption of multivalent polymeric particles
论文作者
论文摘要
多价性是通过分组弱键来形成强可逆键和选择性键的常见生物学机制。聚合物通常充当附着多个结合基团的支架。在这里，我提出了一种分析理论，允许使用关联流体理论中的工具来计算多价聚合物颗粒的亲和力和选择性。我明确考虑了聚合物支架的自由度的构象，并讨论了它们如何影响超选择性。我还考虑了具有两种类型配体的线性聚合物颗粒，并表明超选择性不取决于沿骨架沿骨架的配体的顺序，用于带有短接头的高斯链。
Multivalency is a common biological mechanism of formation of strong reversible and selective bonds by grouping weak bonds. Polymers often act as a scaffold to which multiple binding groups are attached. Here I present an analytical theory allowing to calculate avidity and selectivity for multivalent polymeric particles using tools from the theory of associating fluids. I explicitly take into account conformational degrees of freedom of a polymeric scaffold and discuss how they affect superselectivity. I also consider linear polymeric particles with two types of ligands and show that superselectivity does not depend on the sequence of ligands along the backbone for a Gaussian chain with short linkers.
