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Recent years have witnessed a growing number of attack vectors against increasingly interconnected traffic networks. Informational attacks have emerged as the prominent ones that aim to poison traffic data, misguide users, and manipulate traffic patterns. To study the impact of this class of attacks, we propose a game-theoretic framework where the attacker, as a Stackelberg leader, falsifies the traffic conditions to change the traffic pattern predicted by the Wardrop traffic equilibrium, achieved by the users, or the followers. The intended shift of the Wardrop equilibrium is a consequence of strategic informational poisoning. Leveraging game-theoretic and sensitivity analysis, we quantify the system-level impact of the attack by characterizing the concept of poisoned Price of Anarchy, which compares the poisoned Wardrop equilibrium and its non-poisoned system optimal counterpart. We use an evacuation case study to show that the Stackelberg equilibrium can be found through a two-time scale zeroth-order learning process and demonstrate the disruptive effects of informational poisoning, indicating a compelling need for defense policies to mitigate such security threats.