论文标题

平面软组织双轴机械测试的贝叶斯本构型模型选择框架:应用于猪主动脉瓣

A Bayesian constitutive model selection framework for biaxial mechanical testing of planar soft tissues: application to porcine aortic valves

论文作者

Aggarwal, Ankush, Hudson, Luke T., Laurence, Devin W., Lee, Chung-Hao, Pant, Sanjay

论文摘要

已经开发了用于软组织力学的各种本构模型。但是,没有建立的标准可以为特定应用选择合适的模型。尽管最适合实验数据的模型可以视为最合适的模型,但考虑到实验观察的样本间变异性,这种做法通常不足以造成。在本文中,我们提出了一种贝叶斯方法,以根据组织样品的双轴机械测试来计算组成型模型的相对概率。使用双轴拉伸设置测试了46个猪主动脉瓣组织的样品。对于每个样品,施加了沿着和垂直于纤维方向的七个比率。使用建议的模型选择框架根据实验数据计算了八个基于不变的本构模型的概率。计算出的概率表明,在考虑的模型中,并基于通过使用的实验数据集获得的信息,May-Newman模型是猪主动脉瓣数据的最可能模型。当将样品分组为不同的尖峰类型时,May-Newman模型仍然是左和右转的尖端最可能的,而对于非统治尖端,发现两个模型同样可能:Lee-Sacks模型和May-newman模型。发现尖峰类型之间的这种差异与第一个主体组件分析(PCA)模式相关,其中该模式的非冠状和右cusps的幅度显着差异。我们的结果表明,基于PCA的统计模型可以捕获软组织机械性能的显着差异。提出的框架适用于任何组织类型,并且有可能提供一种结构化和理性的方法来制定基于人群的模拟。

A variety of constitutive models have been developed for soft tissue mechanics. However, there is no established criterion to select a suitable model for a specific application. Although the model that best fits the experimental data can be deemed the most suitable model, this practice often can be insufficient given the inter-sample variability of experimental observations. Herein, we present a Bayesian approach to calculate the relative probabilities of constitutive models based on biaxial mechanical testing of tissue samples. 46 samples of porcine aortic valve tissue were tested using a biaxial stretching setup. For each sample, seven ratios of stresses along and perpendicular to the fiber direction were applied. The probabilities of eight invariant-based constitutive models were calculated based on the experimental data using the proposed model selection framework. The calculated probabilities showed that, out of the considered models and based on the information available through the utilized experimental dataset, the May--Newman model was the most probable model for the porcine aortic valve data. When the samples were grouped into different cusp types, the May--Newman model remained the most probable for the left- and right-coronary cusps, whereas for non-coronary cusps two models were found to be equally probable: the Lee--Sacks model and the May--Newman model. This difference between cusp types was found to be associated with the first principal component analysis (PCA) mode, where this mode's amplitudes of the non-coronary and right-coronary cusps were found to be significantly different. Our results show that a PCA-based statistical model can capture significant variations in the mechanical properties of soft tissues. The presented framework is applicable to any tissue type, and has the potential to provide a structured and rational way of making simulations population-based.

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