论文标题
原核细胞的拓扑:纳米骨会催化裂变吗?
Topology of protocells: do nanoholes catalyse fission ?
论文作者
论文摘要
我们提出了一种基于原蛋白膜拓扑的变化,提出了一种具有低活化能的机制,用于脂质易位。内层和外层连接并形成环形纳米孔,该纳米孔被排斥的静电力稳定,用于小半径,并具有较大半径的有吸引力的弹性力。多亏了这些孔,易位的能量屏障大大降低,而原核内部和外部之间的温度差异可以诱导这些层的差异生长,直到囊泡分为两者为止。
We propose a mechanism with a low activation energy for lipid translocation, based on a change of topology of the membrane of a protocell. The inner and outer layers are connected and form toroidal nanoholes stabilised by repulsive electrostatic forces for small radius and attractive elastic forces for large radius. Thanks to these holes, the energy barrier of translocation is drastically reduced and a difference of temperature between the inside and the outside of the protocell can induce a differential growth of these layers, until the vesicle splits in two.