论文标题
红细胞在微通道中的轴向分散
Axial dispersion of Red Blood Cells in microchannels
论文作者
论文摘要
在微通道中流动的红细胞由于不均匀的速度剖面而在流动方向上进行分散，而由于细胞壁相互作用而引起的横向迁移往往会沿着中心线聚焦。这导致RBC过境时间通过毛细管的分散，该毛细管与它们的横向迁移特性直接相关。通过与泰勒 - 阿里斯（Taylor-Aris）问题类似，我们提出了一种实验方法，可以通过注射红细胞的脉冲并测量其长度沿通道的脉冲来表征这种现象，并测量其长度的演变，以及不同的机械参数，例如RBC可变形性和流体粘度。实验结果与结合纵向对流和横向迁移的模型的直接比较表明，该原理通过简单的分散测量提供了对直接连接到细胞机械性能的迁移特征的评估。
Red Blood Cells flowing in a microchannel undergo dispersion in the flow direction due to the non-uniform velocity profile while transverse migration due to cell-wall interactions tends to focus them along the center line. This results in a dispersion of RBC transit times through a capillary that is directly related to their transverse migration properties. By analogy with the Taylor-Aris problem, we present an experimental method to characterise this phenomenon by injecting pulses of red blood cells and measuring the evolution of their length along the channel, and varying mechanical parameters such as RBC deformability and fluid viscosity. A direct comparison of experimental results with a model that incorporates longitudinal advection and transverse migration shows that this principle provides through a simple dispersion measurement an evaluation of migration characteristics that are directly connected to cell mechanical properties.
